Researchers at the University of Eastern Finland have discovered a novel mechanism safeguarding mitochondrial DNA. The study, published in PNAS earlier this week, was carried out in close ...
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
DNA, often called the blueprint of life, is built from four chemical building blocks known as deoxy-nucleoside triphosphates (dNTPs)—dATP, dTTP, dGTP, and dCTP. Cells constantly need these molecules ...
A newly mapped step in DNA replication suggests that strand separation begins at a precise junction between two helicase ...
MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...
A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...
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