Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.

The two strands of DNA, although chemically equivalent, are replicated and repaired asymmetrically. Insights into the persistence of DNA damage show how strand-specific interactions shape the ...

To date, at least 40 diseases, including many cancers and rare disorders, have been linked to problems with DNA replication. The process begins by unzipping DNA's ladder-like structure, resulting in ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 ...

THE precursor of life may have learned how to copy itself thanks to simple convection at the bottom of the ocean. Lab experiments reveal how DNA replication could have occurred in tiny pores around ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and ...