A new study shows how prostate cancer cells use valine and isoleucine metabolism to sustain cholesterol synthesis under ...

In response to ionising radiation, tumour cells undergo profound metabolic reprogramming that underpins their ability to survive and repair damage. Hallmarks of this process include a shift from ...

Metabolic reprogramming in tumor immunology refers to alterations in nutrient uptake and intracellular pathways that enable both cancer cells and immune cells to survive, proliferate and exert ...

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression. In gynecological malignancies-including ovarian, cervical, and ...

Announcing a new article publication in BIO Integration. Pulmonary fibrosis (PF) is a progressive and irreversible interstitial lung disease that is characterized by destruction of alveolar ...

Therapeutic strategies targeting TAMs. Currently, three primary strategies have been developed to target TAMs, aiming to achieve greater efficacy in tumor treatment. 1. TAM reduction: CSF-1R or ...

Herpes simplex virus (HSV-1) is known to be a potential factor in neurodegeneration and conditions such as Alzheimer's disease, but the exact mechanisms and metabolic consequences of infection are ...

MTAP loss in sarcomatoid renal cell carcinoma (srcRCC): A genomic landscape study. This is an ASCO Meeting Abstract from the 2026 ASCO Genitourinary Cancers Symposium. This abstract does not include a ...

A recent study has demonstrated the power of metabolic engineering in enhancing the antitumor activity of chimeric antigen receptor (CAR) macrophages (CAR-Ms) in solid tumors. By overexpressing the ...

Integrating circulating tumor DNA (ctDNA) and TP53 alteration variant allele frequency (VAF) to predict outcomes in advanced urothelial carcinoma (aUC) treated with enfortumab vedotin (EV).

Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...

For the first time ever, NTNU researchers have identified new characteristics of aggressive prostate cancer. The research lays a foundation for the possibility that aggressive prostate cancer can ...