YouGottaPractice on Instagram: "Explanation: • ✅ A. JAK2 V617F – Correct. Present in ~50–60% of myelofibrosis; drives abnormal proliferation and fibrosis. • ❌ B. CALR – Seen in ~20–25% but less associated with transformation risk than JAK2. • ❌ C. MPL – Found in ~5–10%, but again JAK2 dominates. • ❌ D. BCR-ABL1 – Seen in CML, not primary myelofibrosis."
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YouGottaPractice on Instagram: "Explanation: • ✅ A. JAK2 V617F – Correct. Present in ~50–60% of myelofibrosis; drives abnormal proliferation and fibrosis. • ❌ B. CALR – Seen in ~20–25% but less associated with transformation risk than JAK2. • ❌ C. MPL – Found in ~5–10%, but again JAK2 dominates. • ❌ D. BCR-ABL1 – Seen in CML, not primary myelofibrosis."
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